19 October 2022 (11:09-UTC-07 Tango 06) 27 Mehr 1401/23 Rabi ‘al-Awwal 1444/24 Geng-Xu 4720/19 октября 2022 года
Scientists in the leftist-liberal-progressive state of Massachusetts have created a new Coronavirus with an 80% kill rate! They call it Omi-S.
In a Boston University lab, scientists claiming to be trying to prove that the spikes on viruses (aka Spike Proteins) are the key to their infectiousness, combined different Coronaviruses and apparently created a more deadly virus. By the way, when scientists play god with pathogens this is officially known as Gain of Function.
The just published, yet to be peer reviewed, study is called Role of spike in the pathogenic and antigenic behavior of SARS-CoV-2 BA.1 Omicron, go read it for yourself.
Omi-S is a combination of “…the S gene of Omicron in the backbone of an ancestral SARS-CoV-2 isolate…”, the result of this Gain of Function experiment is “the Omicron S-carrying virus inflicts severe disease with a mortality rate of 80%.” However, the protein spikes have “…an appreciable but minimal role in…pathogenicity”.
“Mutations in the spike RBM are major drivers of Omicron’s escape from neutralization”
But buried within the study is the discovery that the Omicron protein spikes appear to play a major role in protecting the virus from mRNA vaccines: “…we examined if Omi-S captures the immune escape phenotype of Omicron. A large body of literature has demonstrated extensive escape of Omicron from vaccine-induced humoral immunity. We compared the in vitro neutralization activity of sera obtained from vaccinated individuals against the SARS-CoV-2 Washington isolate (USA-WA1/2020), Omi-S, and Omicron. Sera collected within two months of the second dose of mRNA-1273 (Moderna mRNA vaccine; n = 12) or BNT162b2 (Pfizer-BioNTech mRNA vaccine; n = 12) vaccine were included. We performed a multicycle neutralization assay using a setting in which the virus and neutralizing sera were present at all times, mimicking the situation in a seropositive individual. All sera poorly neutralized Omicron, with 11.1-fold (range: 4.4- to 81.2-fold; p < 0.0001) lower half-maximal neutralizing dilution (ND50) for Omicron compared with WA1. In fact, around 80% of samples failed to completely neutralize Omicron at the highest tested concentration.”
Role of spike in immune resistance of Omicron.
a, ND50 values for WA1, Omi-S, and Omicron in sera from individuals who received two shots of Moderna (donor 1-12) or Pfizer (donor 13-24) vaccine (further details of sera are provided in Extended Data Table 1; individual curves are shown in Extended Data Fig. 4). b, Trajectories of ND50 values against WA1, Omi-S, and Omicron (the data from a is plotted). Fold-change in ND50 values is indicated. c,d,e,f, Schematic of the chimeric (top panels; c,d) and mutant (top panels; e,f) viruses. The amino acid numbering for WA1 mutants in e is based on the WA1 spike sequence, whereas the numbering for Omicron mutants in f is based on the Omicron spike sequence. Six of the 24 sera (three from Moderna and three from Pfizer) were tested. Each serum sample is represented by a dot of specific color. The data are plotted as fold-change of the parental virus. Statistical significance was determined using a two-tailed, unpaired t test with Welch’s correction. *p <0.05, **p <0.01, ***p <0.001, and ****p < 0.0001; ns, not significant.
According to the published study’s footnotes, this Gain of Function study was funded by Boston University, and taxpayer funded grants from the U.S. National Institutes of Health (NIH)-National Institute of Allergy and Infectious Diseases. Despite the taxpayer funding coming directly from NIH, the director of the Boston University lab straight-up lied to a reporter about the funding, saying they got no funding from the NIH! Perhaps it is semantics as the National Institute of Allergy and Infectious Diseases is a department of the NIH: “It is a murky world, but in our view because the funding was not supporting the work that was supported in this paper, that it wasn’t necessary to report it to NIH.”-Ronald Corley
This YouTube discussion fails to mention that the study revealed that mRNA vaccines do not work, they just focus on Gain of Function:
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