“Current mRNA delivery methods do not have very effective endosomal escape mechanisms, so the amount of mRNA that actually gets released into cells and shows effect is very low. The majority of them are wasted when they get administered.”-Liangfang Zhang, Zhang Labs/UCSD-Nano Engineering, 30NOV2021
01 December 2021 (13:00-UTC-07 Tango 06) 10 Azar 1400/25 Rabi ‘ath-Thani 1443/27 Geng-Zi (10th month) 4719
Once again, the folks with Zhang Lab, working with the University of California San Diego (UCSD), are pushing the boundaries of still experimental mRNA vaccines.
In October, I wrote how Zhang Labs/UCSD-Department of NanoEngineering are working with the U.S. Army to create new nano-particle ‘nano-sponges’ to make mRNA vaccines more effective (and how the project just happen to coincide with the start of the Pandemic). Turns out that also in October, they published a report describing their experiment with using the ‘shells’ of Influenza A viruses to essentially act as Trojan Horses for mRNA vaccines, tricking your cells into allowing the vaccine in.
The new research also proves that current mRNA Pandemic vaccines don’t work for most people, because most people’s (healthy people’s) endosomal membranes block the still officially experimental vaccines, not allowing ‘endosomal escape‘ to take place.
It is hoped that by using the Trojan Horse Flu virus ‘shell’ that people could be given smaller doses of mRNA vaccine, and possibly reduce the amount of adverse effects. Influenza has a special protein that tricks your cell’s endosomal membrane into letting it come on in and ‘party’ (this is why flu is so infectious), the process of a vaccine connecting with your cell’s membrane and releasing its content into your cell is called endosomal escape.
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